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Closed Loop Medicine Ltd.. (5/17/23). "Press Release: Closed Loop Medicine and Pharmanovia Enter a Co-development Partnership for Precision Medicine Combination Therapeutics". London & Basildon.

Organisations Organisation Closed Loop Medicine Ltd.
  Organisation 2 Pharmanovia UK Ltd.
  Group Pharmanovia (Group)
Products Product personalised medicine / precision medicine
  Product 2 drug development
Persons Person Yadi, Hakim A. (Closed Loop Medicine 202203 CEO + Co-Founder)
  Person 2 Burt, James (Pharmanovia 202305 CEO)

> Pharmanovia’s leading medicine brands to be combined with Closed Loop Medicine’s technology to provide dose optimized personalized therapies

> Global (ex-US) co-development and commercialization partnership to initially focus on next-generation drug + software product solutions for the treatment of hypertension

Closed Loop Medicine Ltd, a leading TechBio company, developing combination prescription drug plus software therapy products that enable personalized dose optimization, and Pharmanovia, a global pharmaceutical company that commercializes novel medicines and revitalizes, extends and expands the lifecycle of established medicines, today announced that they have entered a global co-development partnership.

The partnership will initially focus on the development and launch of a drug + software combination version of a first-line anti-hypertensive in the UK, before phased global roll-out and additional therapies are added.

Hypertension is the leading preventable cause of morbidity and premature death worldwide, impacting over 1 in 4 men and 1 in 5 women, and costing the NHS alone over £2.1 billion/year (1, 2). Managing high-blood pressure through medication and lifestyle modifications significantly reduces associated health risks and improves quality of life; research in the US demonstrating improved standards of care could prevent 91,900 heart attacks, 139,000 strokes and 115,400 cardiovascular deaths within just 5 years (3). However, poor drug tolerability and treatment-related side effects significantly impact adherence, with less than 50% of patients maintaining their treatment regimen after a year, ultimately hindering treatment effectiveness, patient outcomes and overall disease management (4).

As part of this partnership, Closed Loop Medicine’s proprietary Software-as-a-Medical Device (SaMD) dosing optimization technology will be combined with Pharmanovia’s established anti-hypertensive medicines, under a single prescription. Recent preliminary clinical trial results have demonstrated that Closed Loop Medicine’s technology may provide the ability to dose optimize drug therapy, improve blood pressure control, and minimize side effects (5). By developing a new class of combination products for the treatment of hypertension, both companies aim to support patients and healthcare professionals to better manage high blood pressure.

Dr. Hakim Yadi OBE, CEO & Co-Founder of Closed Loop Medicine, commented: “This pioneering partnership is a great example of where the power of software integration can add value to iconic medicines to make them more effective for patients. Through this co-development agreement, we will bring our IP, insight and technical know-how of dose optimized drug plus software integration alongside Pharmanovia’s innovative business model, to enable well-known and trusted brands to be positioned as value-driven precision medicine product solutions globally.”

Dr. James Burt, CEO of Pharmanovia, said: “Combining our experience in lifecycle management with Closed Loop Medicine’s unique approach and technology is an exciting next step in our strategy. It enables us to use innovative technology to enhance established medicines and bring much needed innovation to an area of large-scale unmet need. Together we aim to deliver a first in class combination regulated software and medicine – with the aim of delivering better patient outcomes, while enabling healthcare systems to reduce costly hospital procedures through better adherence and patient engagement.”



3. Yadi H. 2023.

4. Burnier M, Egan BM. Circ Res. 2019;124(7):1124-1140.

5. Taylor M et al. J Am Coll Cardiol. 2022;79(9) suppl 1997


Notes to Editors:

Dr. Hakim Yadi OBE, CEO & Co-Founder, Closed Loop Medicine
Dr. James Burt, CEO, Pharmanovia
For high-resolution images please contact Zyme Communications.

For further information please contact:

Media contact for Closed Loop Medicine

Zyme Communications
Dr. Maria Spyrou
Tel: 07707049640


Alison Dyson, Director of Communications
Email :
Tel : 07912887250

About Closed Loop Medicine

Closed Loop Medicine is a TechBio company developing combination prescription drug plus software products, with the aim of redefining precision medicine. The Company’s proprietary technology platform facilitates personalized drug dosing optimization, through integration of drugs and software with patient-led digital experiences and closed loop models of care. This approach has the potential to provide bespoke universal healthcare access and improve outcomes for patients with chronic diseases. Closed Loop Medicine recently completed a clinical study (PERSONAL COVIDBP) using a leading anti-hypertensive that demonstrated the ability to improve drug tolerability through dose optimization.

To learn more about Closed Loop Medicine and its mission to redefine personalized medicine, please visit:

Follow Closed Loop Medicine on Twitter (@closed_loop_med) and LinkedIn (@Closed Loop Medicine)

About Pharmanovia

Pharmanovia is a global lifecycle management healthcare company. Our purpose is to make medicines fit for tomorrow, to improve the lives of patients globally.

We do this by commercializing novel medicines and technologies as well as rediscovering, repurposing or re-engineering established medicines to improve patient outcomes and experiences.

With a diverse and growing team in over 160 countries across the globe, we deliver high-quality solutions, ethically and sustainably, across our four core therapeutic areas – Endocrinology, Neurology, Cardiovascular and Oncology.

To learn more about Pharmanovia:

Record changed: 2023-09-11


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